Friday, April 13, 2018

DRUG DELIVERY BY DESIGNER MOLECULES

At Indian Institute of Technology  Madras
Department of Chemistry headed by Prof Dillip Kumar Chand 

Prof Dillip Kumar Chand 

Developed designer molecules can be used for drug delivery . This can be done with the cavities inside it.
In the words of  Prof  Chand  "Molecules having a cavity are used for binding the guest molecule and transporting them to another site "

Designer molecule which were made by the researchers looks like a five pointed tips truncated star . Here more than one cavity means , the designer molecules are more powerful in delivery of drugs. The pentagonal structure in chemicals are very rare and according to the researchers " Since we anticipated a pentagonal architecture , it excited us to put our full effort on the project. "

Three components used for making the star molecule are Palladium (II) , molecule 4-4'-bipyridine  and 1,4-phenylenebis(methylene)

Palladium (II) : Can bind to molecules at four places 90 degree apart
 4-4'-bipyridine : Bind to molecules at two ends and is rod shaped

Five measures of these chemical components are simply combined in a single pot under proper environment. Consequently, the participating components arrange themselves in a three dimensional array and hence a star shaped resultant molecule formed
The density functional theory is employed for calculating the architectural structure of the molecule

Palladium is used for the first time for the development of designer molecules.

Friday, April 6, 2018

DIABETES FIVE TYPES

Five types of  diabetes include three serious and two milder forms

Serious :

 1. Young insulin deficient patients.
2. Auto immune diabetes : Original type 1 diabetes.
3. Insulin resistance : cells are unable to use insulin effectively . They are having higher risk of kidney disease.  Leif Groop ( Endocrinologist at Lund University : Sweden ) said " This group has the most to gain from the new diagnostics as they are the ones who are currently most incorrectly treated".

Milder :  40% of the patients, having a form of diabetes related to advanced age



Currently diabetes are diagnosed  in two categories as Type 1 & Type 2

Type 1:
Diagnosed in childhood . Here in 10 % of the cases the gland pancreas do not produce insulin . Insulin is the hormone which regulates blood sugar

Type 2:
Usually find in adults. Here the gland pancreas  produce insulin but in less quantities. It is not sufficient to regulate the sugar level  which is accumulated due to high carbohydrate consumption


Type 2 diabetes is highly variable

Here 'PRECISION MEDICINE' has the role. Here difference between individuals in managing the disease is taken into consideration

Leif Groop said ' This is the first step towards personalized treatment of diabetes . The new classification is a " paradigm shift" in how the disease is viewed.

As per International Diabetes Foundation 420 million people around the world suffer from diabetes and is expected to reach 629 million by 2045.


Reported by medical journal 'The Lancet Diabetes & Endocrinology' 

NIPAH VIRUS